Karl Anders Knutsson, Stanislav Matuska, Paolo Rama
{"title":"疱疹性角膜炎模拟慢性角膜缘干细胞衰竭","authors":"Karl Anders Knutsson, Stanislav Matuska, Paolo Rama","doi":"10.1016/j.xjec.2020.10.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To describe four cases of herpetic keratitis after cultivated limbal stem-cell transplantation (CLET).</p></div><div><h3>Methods</h3><p>Four patients affected by limbal stem cell deficiency (LSCD) caused by alkali burns received CLET. During regular follow-up, epithelial defects were detected and corneal scraping was performed to identify active viral keratitis.</p></div><div><h3>Results</h3><p>Herpetic epithelial keratitis was successfully diagnosed by corneal scraping and polymerase chain reaction of HSV-1 DNA in all four patients affected by epithelial defects. The defects resolved after appropriate therapy with topical and/or systemic antiviral drugs.</p></div><div><h3>Conclusion</h3><p>Epithelial defects due to herpetic keratitis after cultivated limbal stem-cell transplantation may mimic chronic stem-cell deficiency. A low-threshold for corneal scraping can yield rapid identification of herpetic viral DNA allowing for appropriate treatment.</p></div>","PeriodicalId":100782,"journal":{"name":"Journal of EuCornea","volume":"9 ","pages":"Pages 7-9"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.xjec.2020.10.002","citationCount":"0","resultStr":"{\"title\":\"Herpetic keratitis mimicking chronic limbal stem cell failure\",\"authors\":\"Karl Anders Knutsson, Stanislav Matuska, Paolo Rama\",\"doi\":\"10.1016/j.xjec.2020.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To describe four cases of herpetic keratitis after cultivated limbal stem-cell transplantation (CLET).</p></div><div><h3>Methods</h3><p>Four patients affected by limbal stem cell deficiency (LSCD) caused by alkali burns received CLET. During regular follow-up, epithelial defects were detected and corneal scraping was performed to identify active viral keratitis.</p></div><div><h3>Results</h3><p>Herpetic epithelial keratitis was successfully diagnosed by corneal scraping and polymerase chain reaction of HSV-1 DNA in all four patients affected by epithelial defects. The defects resolved after appropriate therapy with topical and/or systemic antiviral drugs.</p></div><div><h3>Conclusion</h3><p>Epithelial defects due to herpetic keratitis after cultivated limbal stem-cell transplantation may mimic chronic stem-cell deficiency. A low-threshold for corneal scraping can yield rapid identification of herpetic viral DNA allowing for appropriate treatment.</p></div>\",\"PeriodicalId\":100782,\"journal\":{\"name\":\"Journal of EuCornea\",\"volume\":\"9 \",\"pages\":\"Pages 7-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.xjec.2020.10.002\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of EuCornea\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452403420300133\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of EuCornea","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452403420300133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
To describe four cases of herpetic keratitis after cultivated limbal stem-cell transplantation (CLET).
Methods
Four patients affected by limbal stem cell deficiency (LSCD) caused by alkali burns received CLET. During regular follow-up, epithelial defects were detected and corneal scraping was performed to identify active viral keratitis.
Results
Herpetic epithelial keratitis was successfully diagnosed by corneal scraping and polymerase chain reaction of HSV-1 DNA in all four patients affected by epithelial defects. The defects resolved after appropriate therapy with topical and/or systemic antiviral drugs.
Conclusion
Epithelial defects due to herpetic keratitis after cultivated limbal stem-cell transplantation may mimic chronic stem-cell deficiency. A low-threshold for corneal scraping can yield rapid identification of herpetic viral DNA allowing for appropriate treatment.
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