RESEARCH OF THE APPLICATION OF CLINDAMYCIN PHOSPHATE IN THE SUCCESSIVE LUNG INFECTION WITH ANAEROBIC BACTERIA AFTER RADIOTHERAPY

Objective:To investigate the therapeutic outcome and effect of Clindamycin Phosphate in the treatment of successive lung infection with anaerobic bacteria after radiotherapy.Materials and Methods:78 patients with malignancy contracting successive lung infection with anaerobic bacteria followed by radiotherapy were randomly divided into 2 groups,41 people (Clindamycin Phosphate treatment group) and 37 people (Miediling control group) Clindamycin phosphate,300～600 mg,Bid or Tid,10～14 days,Miediling 500～750 mg.Bid or once/8h,10～14 days.Result:(1)Both recovery and efficacious rate demonstratd a significant difference respectively between treatment group and control group(68.3% vs 45.9%) (P0.05),(80.5% vs 59.5%)(P0.05);(2)There existed a significant difference in the lethal rate to the bacteria between treatment group and control group(75.6% vs 54.1%)(P0.05);(3)Side effect incidence rate were 22% and 45.9% selarately (P0.05).Conclusion:The application of clindamycin phosphate in the treatment of successive lung infection with anaerobic bacteria after radiotherapy displayed a better effect and smaller side effect.