内质网应激对下丘脑2型糖尿病细胞的影响

Endocrinology and Metabolic Syndrome Pub Date : 2016-06-29 DOI:10.4172/2161-1017.1000243

C. Mesquita, D. Ferreira, Assaly

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引用次数: 11

摘要

未折叠蛋白反应是一种适应性细胞反应，调节蛋白质翻译率以适应特定的外部压力。这种反应已被证明介导程序性细胞死亡和胰岛素抵抗的病理生理条件，如糖尿病。最近，已经证明下丘脑中UPR的药理激活能够通过尚未完全确定的机制刺激食物摄入。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of the Endoplasmic Reticulum Stress on Diabetes Mellitus Type 2 in Hypothalamic Cells

Unfolded protein response is an adaptive cellular response that adjust protein translation rate to specific external stress. This response has been demonstrated to mediate programmed cell death and insulin resistance in pathophysiological conditions such as diabetes. More recently, it has been demonstrated that the pharmacological activation of UPR in the hypothalamus is able to stimulate food intake through mechanism not completely determined.

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Endocrinology and Metabolic Syndrome

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