马来西亚国家心血管疾病数据库(NCVD) -急性冠脉综合征(ACS)登记:我们有何不同?

Wan Azman Wan Ahmad , Robaayah Zambahari , Omar Ismail , Jeyaindran Sinnadurai , Azhari Rosman , Chin Sze Piaw , Imran Zainal Abidin , Sim Kui-Hian
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引用次数: 22

摘要

目的马来西亚NCVD-ACS(国家心血管疾病数据库-急性冠脉综合征)登记处试图确定ACS患者的发病率和人口统计学特征,并确定其中的高危人群。它提供了综合的观点来评估ACS患者的治疗策略和对现有指南的依从性;这对未来的发展有帮助。它还旨在促进使用该数据库的研究。方法研究对象为2006年1月1日至2006年12月31日在马来西亚11个医院收治的st段抬高型心肌梗死(STEMI)、非st段抬高型心肌梗死(NSTEMI)和不稳定型心绞痛(UA)患者。从特征、临床表现、治疗、住院结局和30天结局等方面分析数据。结果共纳入3422例患者,男女比例为3:1,平均年龄59±12岁,平均BMI为25.8±4.4 kg/m2。在整个研究人群中,96%的人至少有一种确定的心血管危险因素。在STEMI人群中,70%接受了纤溶治疗,8%接受了初级经皮冠状动脉介入治疗(PCI)。纤溶治疗从门到针的平均时间为103±143分钟。86%的NSTEMI和91%的UA患者进行了医疗管理,干预率分别为14%和9%。总体住院死亡率和30天死亡率分别为7%和8%。在我们的非传染性疾病- acs登记中,与其他登记相比,受试者在就诊时更年轻,并且具有更高的心血管危险因素患病率,这表明初级预防计划的重要性。大多数患者接受医学治疗,心脏干预率较低,这一因素主要受资源可用性的影响。从门到针的平均时间远高于建议的指导方针,这是一个需要引起注意的问题。结果表明,在改善住院死亡率和30天死亡率方面还有很多机会。
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Malaysian National Cardiovascular Disease Database (NCVD) – Acute Coronary Syndrome (ACS) registry: How are we different?

Objective

The Malaysian NCVD-ACS (National Cardiovascular Disease Database-Acute Coronary Syndrome) registry attempts to determine the incidence and demographic profile of patients with ACS and to identify high risk group among them. It provides a comprehensive view to assess treatment strategies and adherence to existing guidelines for ACS patients; which can help in future development. It also aims to facilitate research using this database.

Methods

The study included patients with ST-segment elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) admitted to 11 participating sites in Malaysia from 1st January 2006 to 31st December 2006. The data were analyzed in terms of characteristics, clinical presentation, treatment, in-hospital outcome and 30-day outcome.

Results

A total of 3422 patients were enrolled, with male to female ratio of 3:1, mean age of 59 ± 12 years and mean BMI of 25.8 ± 4.4 kg/m2. Among total study population, 96% had at least one established cardiovascular risk factor. In STEMI population, 70% received fibrinolytic therapy and 8% proceeded for primary percutaneous coronary intervention (PCI). Mean door-to-needle time for fibrinolytic therapy was 103 ± 143 min. Medical management was conducted for 86% of NSTEMI and 91% UA patients, with intervention for 14% and 9% respectively. The overall in-hospital mortality and 30-day mortality were 7% and 8% respectively.

Conclusion

In our NCVD-ACS registry, when compared with other registries, the subjects were much younger at presentation and had higher prevalence of established cardiovascular risk factors, indicating the importance of primary prevention programme. Majority of the patients were managed medically, with low rates of cardiac interventions, the factor being driven largely by availability of resources. Mean door-to-needle time was much higher than the recommended guidelines, an issue that needs attention. The results indicate many opportunities for improvement of in-hospital and 30-day mortality.

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