大田菁花的生药学、植物化学标准及抗惊厥活性研究

S. S. Shaikh
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摘要

在印度,植物的多样性很好。以植物为基础的药物,在大多数传统药物系统中作为治疗的组成部分。大田葵是豆科植物,传统上具有多种药用价值。本文对以大叶田葵为代表的植物进行了理化和植物化学研究。以水、乙醇和氯仿为萃取溶剂,采用索氏装置对植物物质进行萃取。采用标准化学试剂和方法对桔梗花提取物进行定性测定。本研究对植物花部分进行了化学成分的测定,并对药物的质量进行了考察。结果发现,不同的花提取物可能含有生物碱、甾体、单宁、甾醇、类黄酮等。采用戊四唑(PTZ)致痫模型,测定大田葵花乙醇提取物、水提取物和氯仿提取物(100mg/kg)的抗惊厥活性。提取物显著(*p < 0.01)缩短惊厥持续时间,延缓癫痫发作。研究结果表明,大田菁花具有抗惊厥活性。
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Pharmacognostical, phytochemical standardization and anticonvulsant activity study of sesbania grandiflora flowers
In the India there is a good biodiversity in plants. Plants based medicinal products used as integrated part of treatment on most of traditional systems of medicines. Sesbania grandiflora is a plant which used traditionally for many medicinal used which belongs in family Fabaceae. Present study was about investigated the Physicochemical and Phytochemical studies on selected plant such as Sesbania grandiflora. For the study Soxhlet apparatus was used for extraction of plant materials with using water, ethanol and chloroform as extractive solvents. Standard chemicals and methods were used for the qualitative determination of plant S. grandiflora flowers extract. The study investigation was followed to determine the presence of chemical compound in flowers part of plant as well as to investigate the quality of drug. Result found that the different flower extract may presence of alkaloids, steroids, tannins, sterols, flavonoid etc. The pentylenetetrazol (PTZ) induced seizure model was used for testing anticonvulsant activity of ethanolic, aqueous and chloroform extracts(100mg/kg) of Sesbania grandiflora flowers. The extracts significantly (*p < 0.01) reduced the duration of convulsion and delay onset of seizure. The study results that Sesbania grandiflora flowers has anticonvulsant activity.
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