Randomized Double-blind Clinical Trial Examining the High Intensity Interval Training and Ellagic Acid Effects on Antioxidant, and Oxidative Stress Factors in 0bese Women

Background and Objectives Obesity is one of the most important concerns and problems that threaten health all over the world, and sports activity and healthy diet are the most important ways to treat and prevent it. so, this study aims to evaluate the effect of 12 weeks of high-intensity interval training (HIIT) and Ellagic Acid (EA) supplementation on oxidative/antioxidant markers in obese women. Subjects and Methods In this randomized clinical trial, 56 inactive obese women were randomly divided into four groups of HIIT, EA, EA+HIIT, and Control. The HIIT groups performed the training for 12 weeks including four 4-minute interval running at 85-95% HRpeak, 3 minutes of running at 50-60% HRpeak and 7 minutes of rest interval. EA supplement was administered at a dose of 50 mg/day for 12 weeks. Blood samples were collected from the subjects before and 48 hours after the last session to assess serum levels of glutathione peroxidase (GPx), Malondialdehyde (MDA), and total antioxidant capacity (TAC). Results There was a significant difference between EA+HIIT and HIIT groups in MDA (P=0.005), TAC (P=0.003) and GPx (P=0.0001) after intervention. There was a significant difference between the MDA and TAC values of the subjects in the studied groups after 12 weeks of HIIT with EA supplementation (P=0.0001). And this was the difference between the combined group (EA+HIIT) and other groups. Conclusion Twelve weeks of HIIT and EA supplementation can significantly improve antioxidant and oxidant factors in obese women.