渗透对角质层持水能力及皮肤水合作用的影响

F. Pirot, Bénédicte Morel, G. Peyrot, Tiphaine Vuillet, V. Faivre, Christine Bodeau, F. Falson
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引用次数: 16

摘要

角质层(SC)的特点是具有高度亲水性的化合物,具有渗透特性。渗透在离子透皮给药中的作用一直是众多研究的主题。然而,渗透对SC的持水能力(WHC)和皮肤水化的影响需要澄清。在本研究中,我们发现WHC和皮肤水合作用与渗透压和渗透物的SC渗透性相关。WHC和皮肤水合作用的增强与SC渗透压的增加有关。从化合物的理化参数出发,建立了预测其含水量和皮肤水化的数学模型。
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Effects of Osmosis on Water-Holding Capacity of Stratum corneum and Skin Hydration
The stratum corneum (SC) is characterized by highly hydrophilic compounds exhibiting osmotic properties. The role of osmosis in iontophoretic transdermal drug delivery has been a subject in numerous studies. However, the effects of osmosis on the water-holding capacity (WHC) of SC and skin hydration need to be clarified. In the present study, the WHC and skin hydration were found to be correlated with osmotic pressure and the SC permeability of osmolytes. The WHC and skin hydration enhancement were related to the increase in SC osmolality. A mathematical model was proposed to predict the WHC and skin hydration from physicochemical parameters of compounds.
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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