F. Pirot, Bénédicte Morel, G. Peyrot, Tiphaine Vuillet, V. Faivre, Christine Bodeau, F. Falson
{"title":"渗透对角质层持水能力及皮肤水合作用的影响","authors":"F. Pirot, Bénédicte Morel, G. Peyrot, Tiphaine Vuillet, V. Faivre, Christine Bodeau, F. Falson","doi":"10.1159/000078693","DOIUrl":null,"url":null,"abstract":"The stratum corneum (SC) is characterized by highly hydrophilic compounds exhibiting osmotic properties. The role of osmosis in iontophoretic transdermal drug delivery has been a subject in numerous studies. However, the effects of osmosis on the water-holding capacity (WHC) of SC and skin hydration need to be clarified. In the present study, the WHC and skin hydration were found to be correlated with osmotic pressure and the SC permeability of osmolytes. The WHC and skin hydration enhancement were related to the increase in SC osmolality. A mathematical model was proposed to predict the WHC and skin hydration from physicochemical parameters of compounds.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"21 1","pages":"252 - 257"},"PeriodicalIF":0.0000,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":"{\"title\":\"Effects of Osmosis on Water-Holding Capacity of Stratum corneum and Skin Hydration\",\"authors\":\"F. Pirot, Bénédicte Morel, G. Peyrot, Tiphaine Vuillet, V. Faivre, Christine Bodeau, F. Falson\",\"doi\":\"10.1159/000078693\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The stratum corneum (SC) is characterized by highly hydrophilic compounds exhibiting osmotic properties. The role of osmosis in iontophoretic transdermal drug delivery has been a subject in numerous studies. However, the effects of osmosis on the water-holding capacity (WHC) of SC and skin hydration need to be clarified. In the present study, the WHC and skin hydration were found to be correlated with osmotic pressure and the SC permeability of osmolytes. The WHC and skin hydration enhancement were related to the increase in SC osmolality. A mathematical model was proposed to predict the WHC and skin hydration from physicochemical parameters of compounds.\",\"PeriodicalId\":12086,\"journal\":{\"name\":\"Exogenous Dermatology\",\"volume\":\"21 1\",\"pages\":\"252 - 257\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exogenous Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000078693\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exogenous Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000078693","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Osmosis on Water-Holding Capacity of Stratum corneum and Skin Hydration
The stratum corneum (SC) is characterized by highly hydrophilic compounds exhibiting osmotic properties. The role of osmosis in iontophoretic transdermal drug delivery has been a subject in numerous studies. However, the effects of osmosis on the water-holding capacity (WHC) of SC and skin hydration need to be clarified. In the present study, the WHC and skin hydration were found to be correlated with osmotic pressure and the SC permeability of osmolytes. The WHC and skin hydration enhancement were related to the increase in SC osmolality. A mathematical model was proposed to predict the WHC and skin hydration from physicochemical parameters of compounds.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
