口服缓释片:综述,特别强调矩阵片

G. Agarwal, S. Agarwal, PK Karar, S. Goyal
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引用次数: 50

摘要

在各种给药途径中,口服给药途径是最优选的给药途径。但常规剂型的局限性很小,可以通过修改现有剂型来解决。持续和受控的给药系统有助于维持恒定的血浆药物浓度,延缓药物的释放速度,从而延长作用时间。缓释片的处方策略多种多样,其中基质片是一种重要的处方策略。因此,诸如患者依从性差、多次给药、拉锯式波动等问题可以很容易地最小化。基质片可以通过直接压缩或湿制粒的方法,使用各种亲水性或疏水性聚合物来配制。药物从基质中释放的速度主要取决于水渗透的速度和程度、聚合物的溶胀、药物的溶解和扩散。因此,缓释基质片能提供更好的患者依从性,对慢性疾病的治疗有很大的帮助。本文主要研究口服缓释片,重点介绍了基质片。
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Oral Sustained Release Tablets: An Overview with a special emphasis on Matrix Tablet
Among the various routes of drug delivery oral route is most preferred route. But conventional dosage form offers few limitations which could be resolved by modifying the existing dosage form. Sustained and controlled drug delivery system helps in maintaince of constant plasma drug concentration and retards the release rate of drug therby extending the duration of action. There are various formulation strategies for sustained release tablets among which matrix tablet serves as an important tool. Hence the problem like poor patient compliance, multiple dosing, see-saw fluctuations can be easily minimized. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The rate of drug release from the matrix is primarily goverened by rate & extent of water penetration, swelling of polymer, dissolution & diffusion of drug. Thus, sustained release matrix tablet can offer better patient compliance and could be quite helpful in treatment of chronic diseases. The present article concentrates on oral sustained release tablets with a special emphasis on matrix tablet.
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