补体受体2型(CR2/CD21)作为先天免疫和获得性免疫之间的中心联系

M.D. V. Michael Holers
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引用次数: 1

摘要

补体系统被许多分子激活,包括先天免疫系统的几种重要蛋白质,导致C3激活片段与Ag和/或Ab的共价连锁。C3激活片段的受体,特别是CD21,在连接B淋巴细胞适应性免疫系统和补体系统中起着核心作用。CD21缺陷小鼠表现出明显的免疫缺陷。这些缺陷是明显的,因为CD21在体内B淋巴细胞、FDC和可能的T淋巴细胞的激活中起重要作用。通过阻断配体与CD21的结合或在疫苗接种策略中将Ags靶向到该受体来操纵CD21的活性,目前正在探索作为调节几种人类免疫反应的选择。通过这些和其他策略调节免疫反应可能会进一步确定CD21在连接先天免疫和获得性免疫方面所起的关键作用。
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Complement receptor type 2 (CR2/CD21) as a central link between innate and acquired immunity

The complement system is activated by many molecules, including several important proteins of the innate immune system, that results in the covalent linkage of C3 activation fragments to Ag and/or Ab. Receptors for C3 activation fragments, especially CD21, play central roles in linking the B lymphocyte adaptive immune system to the complement system. CD21 deficient mice demonstrate pronounced immune defects. These defects are apparent because CD21 plays an important role in the activation of B lymphocytes, FDC, and likely T lymphocytes in vivo. Manipulation of CD21 activities by either blocking the binding of ligands to CD21, or targeting Ags to this receptor in vaccination strategies, are currently being explored as options to regulate several human immune responses. The regulation of immune responses through these and other strategies will likely further define the pivotal role CD21 plays in connecting innate to acquired immunity.

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