出生MCV和MCH是预测α地中海贫血性状的较为可靠的参数

IF 3 Q2 Medicine Clinical Medicine Insights-Blood Disorders Pub Date : 2009-01-01 DOI:10.4137/CMBD.S1927

Altaee Akram, Abu Saud Khalida, S. Sawsan, L. Charles

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摘要

为了评估出生时一些简单的血液参数，以作为怀疑α-地中海贫血(ATM)的依据，一项前瞻性研究纳入了连续202例MCV小于或小于95 fl的新生儿，采用HPLC检测Hb Barts。分组分为两组，一组MCV在90-95之间(89例)，另一组MCV在90以下(113例)。作为对照，连续104例MCV≥95 fl的新生儿进行类似检查。已经证实，MCV低于90 fl，特别是MCH≤30 pg时，是存在ATM的有力指标(109/113)。另一方面，MCV在90以上，特别是MCH在30以上，是ATM(70/89)的强烈负面指标。因此，在大多数新生儿中，可以在出生时确定ATM的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Birth MCV and MCH are Quite Reliable Parameters for the Prediction of Alpha Thalassemia Trait

To assess some simple blood parameters at birth that can be used as a basis to suspect α-thalassemia minor (ATM), a prospective study involving 202 consecutive neonates with MCV of less than 95 fl or less were checked for Hb Barts by HPLC. The group was divided into two, one with an MCV of 90-95 (89 cases) and the other with an MCV below 90 (113 cases). For control, 104 consecutive neonates with an MCV ≥ 95 fl were similarly checked. It has been confirmed that an MCV that is below 90 fl, especially with and MCH of ≤30 pg is a strong indicator of the presence of ATM (109/113). On the other hand, MCV of 90 or more, especially with an MCH of 30 or more is a strong negative indicator for ATM (70/89). Firm diagnosis of ATM at birth can thus be secured in majority of neonates.

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