Extracellular matrix components remodeling and lung function parameters in experimental emphysema and allergic asthma: Differences among the mouse strains

Mice are frequently used in experimental models of respiratory diseases due to their ease of manipulation, genetic homogeneity within inbred populations, and possibility of standardizing environmental exposures. However, it is well established that genetic strain variations in mice may exist, which imply changes in extracellular matrix (ECM) composition and degree of ECM remodeling, with potential for major impacts on respiratory mechanics. The lung ECM is mainly composed of fibrous proteins (collagen and elastin), glycoproteins (fibronectin and laminin), proteoglycans (PGs), and glycosaminoglycans (GAGs). The functions of many ECM components are well described, but their role in the pathogenesis of respiratory diseases, such as emphysema and asthma, requires further elucidation. The aim of this review is to address ECM composition, function, and remodeling as well as demonstrate its relationship with the mechanical profile of the lung in different strains of mice subjected to experimental emphysema and allergic asthma.