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引用次数: 1

摘要

继铁之后,锌是人体内含量第二丰富的微量金属。锌在多种细胞功能中起主要作用,如维持免疫健康。锌的这一特性在COVID-19大流行中具有重要意义。研究表明锌通过抑制SARS-CoV RNA聚合酶表现出抗病毒活性。它还能调节炎症反应,调节抗病毒和抗菌免疫。[1,2]研究表明,锌通过改变病毒的融合、复制和病毒蛋白的翻译,对病毒感染产生显著影响。试验表明,补充锌可通过抑制nf - kb依赖性炎症基因的转录,降低COVID - 19患者气道中性粒细胞浸润和TNF-α释放。[1,2]根据最近的研究,锌可以作为病毒性感染(如COVID - 19)的辅助治疗。锌的补充产生抗病毒作用,调节细胞因子风暴,有助于早期恢复,因为它会导致新的核酸和蛋白质合成。[3]锌是一种具有抗病毒特性的必需营养素。进一步的研究对于了解其治疗威胁生命的病毒感染的潜力至关重要。
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Zinc and COVID-19
Editorial After iron, Zinc is the second most abundant trace metal in the human body. Zinc has a main role in various cellular functions such as maintenance of immune health. This property of zinc is of great significance in the COVID-19 pandemic. Studies show that Zinc exhibits antiviral activity through inhibition of SARS-CoV RNA polymerase. It also regulates inflammatory response and modulates antiviral and antibacterial immunity. [1,2] Studies show that Zinc produces significant effect on viral infections by variation in viral fusion, replication and translation of viral protein. Trial show that Zinc supplementation in COVID 19 patients decreased airway neutrophil infiltration and TNF-α release by impeding NF-kB-dependent transcription of inflammatory genes. [1,2] According to recent research Zinc can be used as adjunct therapy for viral life-threatening infections such as COVID 19. Zinc repletion produces anti-viral effects, moderates the cytokine storm, helps in early recovery, as it causes renewed nucleic acid and protein synthesis. [3] Zinc is an essential nutrient that has antiviral properties. Further research is essential to understand its therapeutic potential against life-threatening viral infections.
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