Measuring Entropy Change in a Human Physiological System

The paper presents a novel approach involving the use of Maxwell relations to combine multiple physiological measures to provide a measure of entropy change. The physiological measures included blood pressure (BP), heart rate (HR), skin temperature (ST), electromyogram (EMG), and electrodermal response (EDR). The multiple time-series physiological data were collected from eight subjects in an experimental pilot study conducted at the Human Engineering Laboratory of NASA Langley Research Center. The methodology included data collection during a relaxation period of eighteen minutes followed by a sixty-minute cognitive task. Two types of entropy change were computed: (a) entropy change (ΔS BP ) due to blood pressure, heart rate, and skin temperature and (b) entropy change (ΔS EMG ) due to electromyogram, electrodermal response, and skin temperature. The results demonstrate that entropy change provides a valuable composite measure of individual physiological response to various stressors that could be valuable in the areas of medical research, diagnosis, and clinical practice.