{"title":"肾素血管紧张素系统与2019冠状病毒病(COVID-19):最新综述","authors":"Rolando S Vela Vásquez","doi":"10.7243/2052-4358-8-2","DOIUrl":null,"url":null,"abstract":"Abnormal Renin-Angiotensin System (RAS) activation has a pivotal role in pathogenesis of cardiovascular or metabolic diseases, known risk factors for poor outcomes in COVID-19. An additional tissue RAS imbalance trough interaction of ‘severe acute respiratory syndrome coronavirus 2’ (SARS-CoV-2) with angiotensin-converting enzyme 2 (ACE-2) seems to play a role in pathogenesis of COVID-19. This interaction has raised some questions about safety of RAS-inhibitors use in COVID-19 patients. On the other hand, potential benefits of RAS-inhibitors use have been suggested. This article presents a brief updated review of renin-angiotensin system (RAS) focusing on interaction with SARS-CoV-2 infection, potential risks or benefits of RAS-inhibitors use, and RAS-related therapeutic targets in COVID-19.","PeriodicalId":84943,"journal":{"name":"IRCS medical science: Cardiovascular system","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Renin Angiotensin System and Coronavirus Disease 2019 (COVID-19): An updated review\",\"authors\":\"Rolando S Vela Vásquez\",\"doi\":\"10.7243/2052-4358-8-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abnormal Renin-Angiotensin System (RAS) activation has a pivotal role in pathogenesis of cardiovascular or metabolic diseases, known risk factors for poor outcomes in COVID-19. An additional tissue RAS imbalance trough interaction of ‘severe acute respiratory syndrome coronavirus 2’ (SARS-CoV-2) with angiotensin-converting enzyme 2 (ACE-2) seems to play a role in pathogenesis of COVID-19. This interaction has raised some questions about safety of RAS-inhibitors use in COVID-19 patients. On the other hand, potential benefits of RAS-inhibitors use have been suggested. This article presents a brief updated review of renin-angiotensin system (RAS) focusing on interaction with SARS-CoV-2 infection, potential risks or benefits of RAS-inhibitors use, and RAS-related therapeutic targets in COVID-19.\",\"PeriodicalId\":84943,\"journal\":{\"name\":\"IRCS medical science: Cardiovascular system\",\"volume\":\"10 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IRCS medical science: Cardiovascular system\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7243/2052-4358-8-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IRCS medical science: Cardiovascular system","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7243/2052-4358-8-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Renin Angiotensin System and Coronavirus Disease 2019 (COVID-19): An updated review
Abnormal Renin-Angiotensin System (RAS) activation has a pivotal role in pathogenesis of cardiovascular or metabolic diseases, known risk factors for poor outcomes in COVID-19. An additional tissue RAS imbalance trough interaction of ‘severe acute respiratory syndrome coronavirus 2’ (SARS-CoV-2) with angiotensin-converting enzyme 2 (ACE-2) seems to play a role in pathogenesis of COVID-19. This interaction has raised some questions about safety of RAS-inhibitors use in COVID-19 patients. On the other hand, potential benefits of RAS-inhibitors use have been suggested. This article presents a brief updated review of renin-angiotensin system (RAS) focusing on interaction with SARS-CoV-2 infection, potential risks or benefits of RAS-inhibitors use, and RAS-related therapeutic targets in COVID-19.
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