联合口服避孕药中一种新的雌激素成分:综述

Q3 Medicine Gynecology Pub Date : 2023-01-20 DOI:10.26442/20795696.2022.6.201749
A. U. Hamadyanova, Afzal H. Tuhtaboev, Venera A. Shafieva, Elena A. Kolodyazhnaya, Julia R. Mansurova, A. Muratova, Arina A. Andreeva, Julia A. Muzafarova
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引用次数: 0

摘要

Estetrol (E4)是1965年在孕妇尿液中发现的一种类固醇激素。E4仅在怀孕期间产生,并通过胎盘进入母体血液。其在孕妇血浆中的浓度在妊娠期间增加,在妊娠结束时达到最大值(1 ng/mL)。E4的药理特性使其成为激素治疗和避孕的有前途的药物。迄今为止,II期和III期研究显示E4 15mg与dro螺酮3mg联合使用效果良好,这种联合口服避孕药具有中性代谢作用。然而,关于这种新组合对乳房和骨组织的影响的证据很少。需要进一步的研究来巩固现有的数据,并调查长期使用含有e4的联合口服避孕药与已知的含有炔雌醇和雌二醇的联合口服避孕药相比可能产生的副作用。
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Estetrol: a new estrogen component in combined oral contraceptives: A review
Estetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta. Its concentration in maternal human plasma increases during pregnancy, reaching a maximum by the end of pregnancy (1 ng/mL). The pharmacological properties of E4 make it a promising agent for hormonal therapy and contraception. To date, phase II and III studies have shown promising results with the combination of 15 mg of E4 and 3 mg of drospirenone: this combined oral contraceptive has shown a good effect with a neutral metabolic effect. However, evidence is scarce about the effect of the new combination on the breast and bone tissue. Further studies are needed to consolidate the available data and to investigate possible side effects of prolonged use of E4-containing combined oral contraceptives compared to known ethinylestradiol and estradiol-containing combinations.
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来源期刊
Gynecology
Gynecology Medicine-Obstetrics and Gynecology
CiteScore
0.70
自引率
0.00%
发文量
52
审稿时长
8 weeks
期刊最新文献
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