鞘内治疗中阿片类药物转化的困境

Seminars in Pain Medicine Pub Date : 2003-12-01 DOI:10.1016/j.spmd.2003.10.001

Stuart L Du Pen MD , Anna R Du Pen ARNP, MN

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引用次数: 8

摘要

鞘内腔的阿片类物质转化尚未得到充分的研究或定义。临床医生提供鞘内治疗作为一种选择，在他们的实践往往必须依靠经验为基础的指导方针。脊柱药物力学和脂溶性严重影响阿片类药物的剂量和转化决策。一些基于临床的亲水药物转换指南是有用的，但亲脂药物转换最好基于起始剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The dilemma of opioid conversion in intrathecal therapy

Opioid conversion in the intrathecal space has been poorly studied or defined. Clinicians providing intrathecal therapy as an option in their practice often must rely on experiential-based guidelines. Spinal drug mechanics and lipid solubility heavily influence opioid dosing and conversion decisionmaking. Some clinically based guidelines for hydrophilic drug conversions are useful, but lipophilic drug conversions are best based on starting doses.

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