应用小鼠体外精子发生模型阐明放射治疗相关男性不育症的机制

Radioisotopes Pub Date : 2022-03-15 DOI:10.3769/radioisotopes.71.35

K. Kaminaga, A. Yokoya, Hisanori Fukunaga

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引用次数: 0

摘要

放射治疗中生育能力的保存对治疗后癌症幸存者的生活质量具有重要意义。本研究利用小鼠睾丸组织培养和普通x射线照射器，分析了空间分异辐射场下精子发生的恢复过程，提示精子干细胞迁移可能参与了恢复过程。这些组织培养方法有望为放射治疗相关男性不育症的机制提供新的见解。

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Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio-Therapy-Related Male Infertility

Fertility preservation in radiotherapy is of signiﬁcance for the quality of life among post-treatment cancer survi-vors. In this study, using a mouse testicular tissue culture and a common X-ray irradiator, we analyzed the recovery process of spermatogenesis in spatially fractionated radiation ﬁelds, suggesting that spermatogonial stem cell migration may be involved in the recovery process. These tissue culture approaches are expected to provide a novel insight into the mechanisms of radiotherapy-related male infertility.

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Radioisotopes

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