携带或不携带人类免疫缺陷病毒的丙型肝炎病毒载量的比较

J. Matthews-Greer, G. Caldito, Sharon Adley, R. Willis, Angela C. Mire, R. Jamison, K. McRae, J. King, Wun-ling Chang
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引用次数: 81

摘要

需要更好地了解人类免疫缺陷病毒(HIV)合并感染如何影响丙型肝炎病毒(HCV)感染的过程,以选择能够从当前HCV治疗中受益的HIV患者。1996年6月至2000年3月,在路易斯安那州立大学健康科学中心对1,279名患者的HCV RNA水平进行了量化;这些患者中有28人同时感染了艾滋病毒。采用拜耳支链dna法定量HCV载量,检测下限为0.2 Meq/ml。我们比较了相同年龄范围(23 - 55岁)的HIV和HCV合并感染患者和仅HCV感染患者的中位HCV RNA水平。28例HCV和HIV合并感染患者的中位HCV载量(17.8 Meq/ml)显著高于同龄仅感染HCV的患者(6.1 Meq/ml) (P < 0.05)。两组患者的HCV负荷与年龄或性别无关。显著性差异(R = - 0.4;共感染组HCV载量与CD4计数呈负相关(P < 0.05),共感染组HCV载量分析时CD4计数在6 ~ 1773 /mm3之间。与仅感染HCV的患者相比,同时感染HCV和HIV的患者的HCV载量增加,且HCV载量与CD4计数呈负相关,表明免疫抑制导致对HCV复制的控制下降。此外,我们报告了合并感染的非裔美国人的HCV载量明显高于白种人。
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Comparison of Hepatitis C Viral Loads in Patients with or without Human Immunodeficiency Virus
ABSTRACT A better understanding of how human immunodeficiency virus (HIV) coinfection affects the course of hepatitis C virus (HCV) infection is required to select patients with HIV who would benefit from current HCV therapy. Between June 1996 and March 2000, HCV RNA levels were quantified for 1,279 patients at the Louisiana State University Health Sciences Center; 28 of these patients were coinfected with HIV. HCV loads were quantified by the Bayer branched-DNA assay with a lower limit of detection of 0.2 Meq/ml. We compared the median HCV RNA levels of for patients coinfected with HIV and HCV and patients infected only with HCV who were in the same age range (23 to 55 years). The median HCV load for the 28 patients coinfected with HCV and HIV (17.8 Meq/ml) was significantly greater (P < 0.05) than that for similarly aged patients infected only with HCV (6.1 Meq/ml). The HCV load did not correlate with age or sex for either group of patients. A significant (R = −0.4; P < 0.05) negative correlation was observed between HCV load and CD4 count in the coinfected group, for whom the CD4 counts at the time of HCV load analysis ranged from 6 to 1,773/mm3. The increased HCV load in patients coinfected with HCV and HIV compared to that in patients infected only with HCV and the inverse relationship of the HCV load to the CD4 count indicate that immunosuppression results in decreased control of HCV replication. In addition, we report significantly higher HCV loads among coinfected African Americans than Caucasians.
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