J. Cieślak, J. Jankowska, M. Sobkowski, M. Wenska, J. Stawinski, A. Kraszewski
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引用次数: 6
摘要
h -膦酸核苷单酯与苯酚在冷凝剂存在下的反应，随后用碘水或单质硫氧化原位生成的芳基h -膦酸核苷二酯，提供了一种新的，“一锅”，高效的进入磷酸核苷或硫代核苷二酯，含有不同的芳基部分。
Aryl H-phosphonates. Part 13. A new, general entry to aryl nucleoside phosphate and aryl nucleoside phosphorothioate diesters
The reaction of nucleoside H-phosphonate monoesters with phenols in the presence of a condensing agent, followed by oxidation of the in-situ-generated aryl nucleoside H-phosphonate diesters with iodine–water or with elemental sulfur, provides a new, ‘one-pot’, efficient entry to nucleoside phosphate or nucleoside phosphorothioate diesters bearing diverse aryl moieties.
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