伊拉克巴士拉地区社区药房患者局部糖皮质激素滥用情况

Alhassan Shaker Abed, Jubran K Hassan
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引用次数: 1

摘要

自糖皮质激素问世以来,由于其抗炎、抗增殖、血管收缩和免疫抑制的特性,局部糖皮质激素一直是治疗许多皮肤疾病的主要药物。在伊拉克,不同效价的外用糖皮质激素作为非处方药物,鼓励将其用于无标签适应症,从而增加了这类药物的副作用。目的:本研究的目的是评估局部糖皮质激素的使用,患者的知识和患者教育。方法:在整个巴士拉市进行了一项基于社区药房的横断面调查。纳入标准为:年龄在15岁及以上且愿意参加研究的到社区药店购买非处方外用皮质类固醇的顾客。在巴士拉市中心和各区发放了600份外用皮质类固醇问卷。600份表格中有254份已归还,其中212份已完成。不完整的表格被排除在外。结果:212名参与者中有106名(50%)滥用局部糖皮质激素。作为单一产品,参与者主要使用倍他米松evalerate和丙酸氯倍他索,它们分别是强效和超高效的外用类固醇。外用类固醇处方的主要来源是亲属,49.8%的参与者没有意识到外用糖皮质激素的任何副作用,而色素沉着是参与者发现的最多的副作用(21.8%)。只有35%的参与者接受过关于糖皮质激素使用的教育,这些参与者是由医生和药剂师提供局部类固醇处方的。结论:局部糖皮质激素在巴士拉市和伊拉克其他城市普遍滥用。在伊拉克,美白和改善面容是一种普遍的文化信仰,这促使人们从社区药房寻求局部糖皮质激素来美白皮肤,此外还有其他未经批准的无处方药物。
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Abuse of Topical Glucocorticoids among Patients Visiting Community Pharmacy in Basrah-Iraq
Introduction: Topical glucocorticoids have been the mainstay for the treatment of many skin conditions sincetheir introduction due to their anti-inflammatory, anti-proliferative vasoconstrictive and immunosuppressiveproperties.Availability of topical glucocorticoids in different potencies as over the counter medication inIraq encourages their use for non-labeled indications , thus increasing the side effect of such drugs.Objectives: The aim of this study was toevaluate the use, knowledge of the patients and patient educationoftopical glucocorticoids.Methodology: A cross sectional community pharmacy based survey was conducted throughout Basrahcity.Inclusion criteria were costumers visiting the community pharmacies asking for topical corticosteroidswithout prescription, aging 15 years and older and willing to participate in the study.600 questionnaireformafor topical corticosteroids were distributed in the center and the districts of Basrah city. 254 forma outof 600 were returned out of which 212 were completed. Incomplete forma were excluded.Result: 106 (50%) participants out of 212misused topical glucocorticoids. As a single product, Betamethasonevalerate and Clobetasol propionate was majorly used by the participants which are potent and ultra-highpotent topical steroid respectively. The major source of topical steroid prescription was relatives.49.8%participants didn’t recognize any side effect of topical glucocorticoids while hypopigmentation was themost side effect identified by the participants (21.8%).Only 35% of the participants,whom topical steroidprescription source by physicians and pharmacists, was educated about the use of topical glucocorticoids.Conclusion: Topical glucocorticoids are commonly abused in Basrah city and probably other cities of Iraq.Looking fair and improving face appearance is a common cultural believe in Iraq that push people to seektopical glucocorticoids from community pharmacies for skin lightening in addition to other unapprovedindications without prescription.
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