肠道微生物群——自闭症谱系障碍的环境致病因素和潜在治疗靶点

Jun Zhou
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版权所有:©2017周建明。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。自闭症谱系障碍(ASD)是一种影响大约1-2%人口的神经发育性精神障碍。ASD患者表现出广泛的症状,包括社交互动困难、沟通能力下降、活动受限和重复行为[1]。既往研究认为ASD的病因包括遗传因素和环境因素[2]。截至目前,在ASD患者中已鉴定出200多个不同遗传模式的易感基因[3]。同时,肠道菌群作为重要的环境因素,在ASD的发展和治疗中发挥了关键作用。
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The Gut Microbiota - The Environmental Causative Factor and thePotential Therapeutic Targets of Autism Spectrum Disorder
Copyright: © 2017 Zhou JM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Autism spectrum disorder (ASD) is a neurodevelopment mental disorder affecting approximately 1-2% of the population. ASD patients displayed a wide range of symptoms including social interaction difficulties, decreased communication skills, restricted activities and repetitive behavior [1]. The etiology of ASD involves both genetic and environmental factors according to previous research [2]. Up to now, more than 200 susceptible genes have been identified in ASD patients with different patterns of inheritance [3]. Meanwhile, the gut microbiota emerged as important environmental factors and played a pivotal role in the development and treatment of ASD.
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