斯里兰卡痴呆症研究活动综述

Abhayasinghe Kalpani, Dissanayake Lasith, S. Benjamin, C. Paul, Sumathipala Athula
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引用次数: 0

摘要

背景:由于全球预期寿命的延长,痴呆症已成为一个主要的全球健康问题;它被认为是晚年生活中最沉重的负担之一。尽管66%的老年痴呆症患者生活在低收入和中等收入国家,但这些国家仅开展了10%的痴呆症研究,需要更多关于低收入和中等收入国家研究活动的信息,以便为全球痴呆症研究战略提供信息。尽管斯里兰卡是该地区人口老龄化速度最快的国家,但迄今尚未对斯里兰卡报告的痴呆症研究的现有证据进行系统评价。目的:描述在斯里兰卡进行的痴呆症研究活动。方法:系统检索各数据库(MEDLINE、EMBASE、PsycINFO、AMED、CINAHL、SLJOL、Cochrane Library)及灰色文献,检索时间为各数据库建立至2020年4月。采用预先定义的纳入和排除标准,对论文进行筛选和质量评估。个别研究的研究活动被划分为四个研究领域。对痴呆研究活动进行了叙述性综合描述。研究结果和结论:在检索到的971篇论文中,有28篇研究纳入了本综述。结果显示了四个研究领域的证据;流行病学(n = 6)、病理生理学(n = 4)、痴呆症筛查(n = 13)和痴呆症管理(n = 7)。与国际健康结果测量联合会(ICHOM)制定的痴呆症标准相比,本综述发现斯里兰卡普遍缺乏痴呆症研究活动,也缺乏高质量的研究,特别是在痴呆症患病率、痴呆症护理、正式和非正式护理者的特征、以及为痴呆症患者及其家人提供的服务。有必要开展更多具有可靠方法的高质量研究,这将为斯里兰卡为痴呆症患者提供政策和服务提供信息。
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Dementia Research Activity in Sri Lanka: A Review
Background: As a result of the global rise in life expectancy, dementia has become a major global health concern; it is considered to be one of the most burdensome conditions of later life. Despite 66% of older adults with dementia living in Low-and-Middle Income countries (LMIC), only 10% of dementia research has been conducted in these countries and more information is needed about research activity within LMIC to inform on global dementia research strategies. Todate no systematic reviews have been carried out to explore existing evidence of dementia research reported from Sri Lanka, despite it having the fastest ageing population in the region. Objective: To describe dementia research activity conducted in Sri Lanka. Method: Systematic searches of databases (MEDLINE, EMBASE, PsycINFO, AMED, CINAHL, SLJOL, Cochrane Library) and grey literature were conducted from each database inception to April 2020. Pre-defined inclusion and exclusion criteria were applied and papers were screened and quality assessed. Research activity by individual studies were mapped into four research domains. A narrative synthesis was conducted to describe dementia research activity. Findings and conclusions: Out of 971 papers retrieved from searches, 28 studies were included in the review. Results show evidence across four research domains; epidemiology (n = 6), pathophysiology (n = 4), screening for dementia (n = 13), and dementia management (n = 7). In comparison to the International Consortium for Health Outcome Measurement (ICHOM) standard set for dementia, this review found a lack of dementia research activity in Sri Lanka generally, as well as a lack of high-quality research, particularly in the areas of dementia prevalence, dementia care, characteristics of formal and informal caregivers, and service provision for people with dementia and their and families. There is a need for more high-quality research, with robust methodologies, which would inform policy and service provision in Sri Lanka for people with dementia.
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