纳米乳剂:靶向给药治疗癫痫

N. V. L. Suvarchala, Reddy V a, M. G. Raju, Keerthana Edunoori, Jyothi Papani
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引用次数: 0

摘要

全世界有5000万人患有癫痫;它在财政、社会和健康方面给社会带来了巨大的负担。在过去的十年中,我们对导致疾病的病理生理过程和影响其预后的因素的理解有了显著的进步。尽管抗癫痫药物的数量在过去20年里急剧增加,但仍有大约三分之一的患者对医疗干预有抵抗力。基于纳米技术的抗癫痫药物(AED)给药方法能够穿过血脑屏障,增加特异性,并具有延长脑给药的能力,最近引起了人们的兴趣。纳米技术似乎是这一领域的一个有前途的创新发展。纳米乳液的平均液滴尺寸为20至200纳米,在乳化剂或乳化剂的帮助下保持两种不相容液体的动力学稳定分散。NEs作为中枢神经系统活性药物的递送系统,用于治疗难以治疗的中枢神经系统疾病的有效方案。
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Nano Emulsion: The Targeted Drug Delivery in the Therapy of Epilepsy
Around the world, 50 million people suffer with epilepsy; it significantly burdens society in terms of finances, society, and health. Our comprehension of the pathophysiological processes causing the illness and the factors affecting its prognosis has significantly advanced during the last ten years. Around a third of patients are still resistive to medical intervention, despite the fact that the number of antiepileptic drugs has expanded dramatically over the past 20 years. The ability of nanotech-based anti-epileptic drug (AED) administration methods to cross the blood brain barrier, increase specificity, and have the capacity for extended brain administration of drugs have lately attracted interest. Nanotechnology appears to be a promising and innovative development in this area. Nano emulsions have a mean droplet size of 20 to 200 nm and remain kinetically stable dispersions of two incompatible liquids with the assistance of an emulsifier or emulsifiers. The effectiveness of NEs as a delivery system for Central Nervous System-active medications used in effective regimens against difficult-to-treat CNS conditions.
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