{"title":"基于ewood的数字微流体半月板辅助磁珠捕获用于特定蛋白质定位","authors":"G. J. Shah, E. Pierstorff, D. Ho, C. Kim","doi":"10.1109/SENSOR.2007.4300228","DOIUrl":null,"url":null,"abstract":"This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs (\"MB-Abs\") as proof of concept.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"22 1","pages":"707-710"},"PeriodicalIF":0.0000,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Meniscus-Assisted Magnetic Bead Trapping on Ewod-Based Digital Microfluidics for Specific Protein Localization\",\"authors\":\"G. J. Shah, E. Pierstorff, D. Ho, C. Kim\",\"doi\":\"10.1109/SENSOR.2007.4300228\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs (\\\"MB-Abs\\\") as proof of concept.\",\"PeriodicalId\":23295,\"journal\":{\"name\":\"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference\",\"volume\":\"22 1\",\"pages\":\"707-710\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/SENSOR.2007.4300228\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/SENSOR.2007.4300228","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Meniscus-Assisted Magnetic Bead Trapping on Ewod-Based Digital Microfluidics for Specific Protein Localization
This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs ("MB-Abs") as proof of concept.
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