耐药结核与糖尿病合并的患病率及主要指标

L. Todoriko, I. Semianiv
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摘要

背景。糖尿病是结核病发生的背景,这种合并症不仅使结核病的具体过程显著复杂化,而且是结核病复发的主要危险因素之一。目标。该研究的目的是对结核病和糖尿病合并进行全面的回顾性评估。材料和方法。我们的研究是基于对762例回顾性研究的统计数据的分析。结果。根据患者结核病病例的类型,我们发现在研究的两组中,结核病的复发率普遍存在——49例(55.7%)对主要组的39例(44.3%);363例(53.9%),对照组311例(46.1%)(p<0.05)。2组治疗成功率明显高于1组(64.7% vs. 61.4%)。然而,更显著的可能差异表现在治疗率上,主组为27.3%,对照组为40.3%(几乎是2倍)。治疗无效的比率,在有合并症的患者中为27.3%(几乎每三名患者中就有一例),而在第二组中为17.6%,这对科学家和从业人员来说也很重要。结论。中年2型糖尿病患者中、重度伴发肺结核的发生率较高,为亚代偿型,病程复杂。在糖尿病患者中,更常记录到肺部常见的结核过程,所有患者中100%记录到共生性细菌排泄。
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Prevalence and main indicators of the combination of resistant tuberculosis and diabetes mellitus
Background. Diabetes is the background for the development of tuberculosis (TB) and such comorbidity not only significantly complicates the specific process, but also is one of the main risk factors for TB recurrence. Objective. The aim of the study is a comprehensive retrospective assessment of the combination of TB and diabetes. Materials and methods. Our study is based on an analysis of statistical data obtained from a retrospective study of 762 case histories. Results. Depending on the type of TB case in our patients, we found that in both groups of the study the recurrence of TB prevailed – 49 cases (55.7 %) against 39 cases (44.3 %) of people in the main group; 363 cases (53.9 %) against 311 (46.1 %) in the control group (p<0.05). The rate of successful treatment in group 2 is probably higher than in group 1 (64.7 % vs. 61.4 %). However, a more significant probable difference is characterized by the treatment rate, which in the main group is 27.3 % vs 40.3 % in the control group (almost 2 times). The rate of ineffective treatment, which in patients with comorbidity was 27.3 % (almost every third patient) against 17.6 % in group 2 is also important for scientists and practitioners. Conclusions. The pulmonary TB developed significantly more often in middle-aged patients with type 2 diabetes mellitus with moderate and severe states, the subcompensated form, with a complicated course. In patients with diabetes more often was registered a common tuberculous process in the lungs and in all 100 % of patients with syntropy bacterial excretion was registered.
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