O. Papaioannou, T. Karampitsakos, P. Tsiri, Vagia Karageorgou, A. Papaioannou, M. Kallieri, M. Blizou, Stefanos Lampadakis, M. Sfika, Antonios Krouskos, Vasilis Papavasileiou, Franceska Strakosha, Kalliopi-Theoni Vandorou, Pavlos Siozos, Marina Moustaka Christodoulou, Georgia Kontonasiou, V. Apollonatou, E. Antonogiannaki, C. Kyriakopoulos, C. Aggelopoulou, C. Chronis, K. Kostikas, E. Koukaki, Z. Sotiropoulou, A. Athanasopoulou, P. Bakakos, Pinelopi Sxini, Emmanouil Alevrakis, Sotirios Poupos, Evangelia Xondrou, Dionisios Tsoukalas, Alexia Chronaiou, G. Tsoukalas, S. Koukidou, G. Hillas, K. Dimakou, K. Roukas, Ifigenia Nakou, D. Chloros, E. Fouka, S. Papiris, S. Loukides, A. Tzouvelekis
{"title":"希腊七个参考中心收治的COVID-19患者的流行病学特征、临床特征和结局:一项在COVID-19大流行第四和第五波期间的观察性研究","authors":"O. Papaioannou, T. Karampitsakos, P. Tsiri, Vagia Karageorgou, A. Papaioannou, M. Kallieri, M. Blizou, Stefanos Lampadakis, M. Sfika, Antonios Krouskos, Vasilis Papavasileiou, Franceska Strakosha, Kalliopi-Theoni Vandorou, Pavlos Siozos, Marina Moustaka Christodoulou, Georgia Kontonasiou, V. Apollonatou, E. Antonogiannaki, C. Kyriakopoulos, C. Aggelopoulou, C. Chronis, K. Kostikas, E. Koukaki, Z. Sotiropoulou, A. Athanasopoulou, P. Bakakos, Pinelopi Sxini, Emmanouil Alevrakis, Sotirios Poupos, Evangelia Xondrou, Dionisios Tsoukalas, Alexia Chronaiou, G. Tsoukalas, S. Koukidou, G. Hillas, K. Dimakou, K. Roukas, Ifigenia Nakou, D. Chloros, E. Fouka, S. Papiris, S. Loukides, A. Tzouvelekis","doi":"10.18332/pne/163036","DOIUrl":null,"url":null,"abstract":"INTRODUCTION Epidemiological data from hospitalized patients with COVID-19 during the fourth and fifth waves of the pandemic have been published worldwide. METHODS This registry was an observational, prospective study conducted in seven reference hospitals across Greece. Maximum FiO 2 during hospitalization and Charlson comorbidity index (CCI) on admission were correlated with disease severity, as well as radiological features, parameters of complete blood count, and d-dimer. RESULTS A total of 1019 patients were included in the analysis; 55.1% and 57.2% of patients were males and never smokers, respectively, with median age of 67 years (95% CI: 65.7–69.0). Patients with increased extent of consolidation and ground glass opacities in chest CT (>10–25%) exhibited more advanced disease compared to the low extent group (<10%) as indicated by both CCI on admission (3; 95% CI: 2–3 vs 2; 95% CI: 1–2, p=0.0002) and MaxFiO 2 (0.40; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.24–0.28, p<0.0001). Patients with high neutrophil to lymphocyte ratio (≥4.42) exhibited more severe disease as indicated by significantly increased CCI on admission (4; 95% CI: 3 to 4 vs 3; 95% CI: 2–3, p<0.0001) and MaxFiO 2 (0.35; 95% CI: 0.35–0.4 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). Patients with elevated d-dimer (≥0.74 μg/mL) displayed also advanced disease compared to the low d-dimer group (<0.74 μg/mL), as assessed by both CCI on admission (4; 95% CI: 4–4 vs 2; 95% CI: 2–2, p<0.0001) and MaxFiO 2 (0.38; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). CONCLUSIONS We present the first observational study across Greece during the fourth and fifth waves of the COVID-19 pandemic. Extent of opacities in chest CT, neutrophil to lymphocyte ratio and d-dimer may represent reliable disease prognostic factors leading to timely therapeutic interventions.","PeriodicalId":42353,"journal":{"name":"Pneumon","volume":"63 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiological characteristics, clinical features\\nand outcomes of patients with COVID-19 admitted\\nto seven reference centers across Greece: An\\nobservational study during the fourth and fifth waves\\nof the COVID-19 pandemic\",\"authors\":\"O. Papaioannou, T. Karampitsakos, P. Tsiri, Vagia Karageorgou, A. Papaioannou, M. Kallieri, M. Blizou, Stefanos Lampadakis, M. Sfika, Antonios Krouskos, Vasilis Papavasileiou, Franceska Strakosha, Kalliopi-Theoni Vandorou, Pavlos Siozos, Marina Moustaka Christodoulou, Georgia Kontonasiou, V. Apollonatou, E. Antonogiannaki, C. Kyriakopoulos, C. Aggelopoulou, C. Chronis, K. Kostikas, E. Koukaki, Z. Sotiropoulou, A. Athanasopoulou, P. Bakakos, Pinelopi Sxini, Emmanouil Alevrakis, Sotirios Poupos, Evangelia Xondrou, Dionisios Tsoukalas, Alexia Chronaiou, G. Tsoukalas, S. Koukidou, G. Hillas, K. Dimakou, K. Roukas, Ifigenia Nakou, D. Chloros, E. Fouka, S. Papiris, S. Loukides, A. Tzouvelekis\",\"doi\":\"10.18332/pne/163036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION Epidemiological data from hospitalized patients with COVID-19 during the fourth and fifth waves of the pandemic have been published worldwide. METHODS This registry was an observational, prospective study conducted in seven reference hospitals across Greece. Maximum FiO 2 during hospitalization and Charlson comorbidity index (CCI) on admission were correlated with disease severity, as well as radiological features, parameters of complete blood count, and d-dimer. RESULTS A total of 1019 patients were included in the analysis; 55.1% and 57.2% of patients were males and never smokers, respectively, with median age of 67 years (95% CI: 65.7–69.0). Patients with increased extent of consolidation and ground glass opacities in chest CT (>10–25%) exhibited more advanced disease compared to the low extent group (<10%) as indicated by both CCI on admission (3; 95% CI: 2–3 vs 2; 95% CI: 1–2, p=0.0002) and MaxFiO 2 (0.40; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.24–0.28, p<0.0001). Patients with high neutrophil to lymphocyte ratio (≥4.42) exhibited more severe disease as indicated by significantly increased CCI on admission (4; 95% CI: 3 to 4 vs 3; 95% CI: 2–3, p<0.0001) and MaxFiO 2 (0.35; 95% CI: 0.35–0.4 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). Patients with elevated d-dimer (≥0.74 μg/mL) displayed also advanced disease compared to the low d-dimer group (<0.74 μg/mL), as assessed by both CCI on admission (4; 95% CI: 4–4 vs 2; 95% CI: 2–2, p<0.0001) and MaxFiO 2 (0.38; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). CONCLUSIONS We present the first observational study across Greece during the fourth and fifth waves of the COVID-19 pandemic. Extent of opacities in chest CT, neutrophil to lymphocyte ratio and d-dimer may represent reliable disease prognostic factors leading to timely therapeutic interventions.\",\"PeriodicalId\":42353,\"journal\":{\"name\":\"Pneumon\",\"volume\":\"63 1\",\"pages\":\"\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pneumon\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18332/pne/163036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pneumon","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18332/pne/163036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Epidemiological characteristics, clinical features
and outcomes of patients with COVID-19 admitted
to seven reference centers across Greece: An
observational study during the fourth and fifth waves
of the COVID-19 pandemic
INTRODUCTION Epidemiological data from hospitalized patients with COVID-19 during the fourth and fifth waves of the pandemic have been published worldwide. METHODS This registry was an observational, prospective study conducted in seven reference hospitals across Greece. Maximum FiO 2 during hospitalization and Charlson comorbidity index (CCI) on admission were correlated with disease severity, as well as radiological features, parameters of complete blood count, and d-dimer. RESULTS A total of 1019 patients were included in the analysis; 55.1% and 57.2% of patients were males and never smokers, respectively, with median age of 67 years (95% CI: 65.7–69.0). Patients with increased extent of consolidation and ground glass opacities in chest CT (>10–25%) exhibited more advanced disease compared to the low extent group (<10%) as indicated by both CCI on admission (3; 95% CI: 2–3 vs 2; 95% CI: 1–2, p=0.0002) and MaxFiO 2 (0.40; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.24–0.28, p<0.0001). Patients with high neutrophil to lymphocyte ratio (≥4.42) exhibited more severe disease as indicated by significantly increased CCI on admission (4; 95% CI: 3 to 4 vs 3; 95% CI: 2–3, p<0.0001) and MaxFiO 2 (0.35; 95% CI: 0.35–0.4 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). Patients with elevated d-dimer (≥0.74 μg/mL) displayed also advanced disease compared to the low d-dimer group (<0.74 μg/mL), as assessed by both CCI on admission (4; 95% CI: 4–4 vs 2; 95% CI: 2–2, p<0.0001) and MaxFiO 2 (0.38; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). CONCLUSIONS We present the first observational study across Greece during the fourth and fifth waves of the COVID-19 pandemic. Extent of opacities in chest CT, neutrophil to lymphocyte ratio and d-dimer may represent reliable disease prognostic factors leading to timely therapeutic interventions.
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