异丙醇钛介导羰基化合物还原胺化制备n -甲基仲胺

Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-18 DOI:10.1039/A803703E

K. A. Neidigh, M. Avery, J. Williamson, S. Bhattacharyya

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引用次数: 38

摘要

报道了一种简单、温和、高效的从醛类和酮类中提取n -甲基仲胺的方法。用盐酸甲胺、三乙胺和异丙醇钛(IV)处理羰基化合物，然后进行原位硼氢化钠还原和直接的水处理，可获得收率高至优异的清洁产品。

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Facile preparation of N-methyl secondary amines by titanium(IV) isopropoxide-mediated reductive amination of carbonyl compounds

A simple, mild and efficient procedure for obtaining N-methyl secondary amines from aldehydes and ketones is reported. Treatment of carbonyl compounds with methylamine hydrochloride, triethylamine and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction and straightforward aqueous work-up, affords clean products in good to excellent yields.

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Journal of The Chemical Society-perkin Transactions 1

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