胃内球囊与肉毒毒素注射短期减肥效果比较

M. Al
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摘要

目的:比较内镜下胃内球囊(IGB)放置和胃内肉毒毒素a (BTX-A)注射对非病态肥胖患者体重减轻的影响。方法:回顾性单中心研究于2020年1月1日至2022年1月1日进行。研究共纳入39例体重指数(BMI) <40且无合并症的患者。19例胃内注射BTX-A, 20例放置IGB。术后1个月和6个月对患者进行评估。结果:BTX-A组患者平均年龄39.4±8.6岁,IGB组患者平均年龄37.3±10.4岁(p = 0.496)。BTX-A组78.9%、IGB组75.0%为女性(p = 1.000)。两组患者术后1个月的中位体重均显著低于术前,术后6个月的中位体重均显著低于术后1个月(两组均p<0.001)。IGB组在第1个月和第6个月的中位体重减轻量均显著大于BTX-A组(p < 0.001)。结论:通过干预后1个月和6个月的体重减轻来衡量,IGB插入似乎是一种比胃内注射BTX-A更成功的内镜减肥手术。对于BMI低于40且无肥胖相关合并症的患者,IGB可能是首选。
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Comparison of The Short-Term Effects of Intragastric Balloon and Botulinum Toxin Injection On Weight Loss
Aim: To compare the effects of endoscopic intragastric balloon (IGB) placement and intragastric botulinum toxin-A (BTX-A) injection in terms of weight loss among patients with non-morbid obesity. Methods: This retrospective single center study was conducted between 01.08.2020 and 01.01.2022. A total of 39 patients with a body mass index (BMI) of <40 without comorbidities were included in the study. Nineteen underwent intragastric BTX-A injection and 20 underwent IGB placement. Patients were evaluated 1 month and 6 months after the procedures. Results: Mean age was 39.4 ± 8.6 in the BTX-A group and 37.3 ± 10.4 in the IGB group (p = 0.496). 78.9% of the BTX-A group and 75.0% of the IGB group were female (p = 1.000). In both groups, the median weight 1 month after the procedure was significantly lower than before the procedure, and the median weight 6 months after the procedure was significantly lower than 1 month after the procedure (p<0.001 for both groups). The median weight loss in the IGB group at both the 1st and 6th months was significantly greater than the corresponding values of the BTX-A group (p < 0.001 for both). Conclusion: IGB insertion appears to be a more successful endoscopic bariatric procedure than intragastric BTX-A injection, as measured by weight loss at post-intervention 1 month and 6 months. IGB may be preferred in patients with a BMI below 40 without obesity-related comorbidity.
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