Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications

The impact of personalized medicine is potentially enormous, but the genetic results are often difficult to integrate into health settings. A number of research studies are emerging to aid in translating pharmacogenomics into clinical practice. We aimed to create a standardized process to guide the implementation of dose adjustment recommendations into the electronic health record (EHR). Monographs were created for selected drug-gene pairs allowing for standardized review of available evidence. A scoring template was developed to assess whether the evidence presented in the drug monograph qualified said drug-gene pair for Clinical Decision Support (CDS) within the EHR. Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to the institution’s governing pharmacogenomics committee. This project resulted in the development of a standard process for review to analyze pharmacogenomics literature allowing for CDS proposals.