(+)-多毒素的全合成

Journal of The Chemical Society, Chemical Communications Pub Date : 2010-06-13 DOI:10.1039/C39950002127

A. Dondoni, F. Junquera, F. Merchant, P. Merino, T. Tejero

{"title":"(+)-多毒素的全合成","authors":"A. Dondoni, F. Junquera, F. Merchant, P. Merino, T. Tejero","doi":"10.1039/C39950002127","DOIUrl":null,"url":null,"abstract":"The antifungal antibiotic, polyoxin J 1, has been obtained (46.4%) by the coupling of a protected derivative of 5-O-carbamoylpolyoxamic acid 2 with thymine polyoxin C 3 which were prepared by a stereoselective aminohomologation strategy of sugar aldehydes (L-threose and dialdo-D-ribofuranose) employing nitrones 4 and 5 as their iminium derivatives and furan as a carboxylate group equivalent.","PeriodicalId":17282,"journal":{"name":"Journal of The Chemical Society, Chemical Communications","volume":"118 1","pages":"2127-2128"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"Total synthesis of (+)-polyoxin J\",\"authors\":\"A. Dondoni, F. Junquera, F. Merchant, P. Merino, T. Tejero\",\"doi\":\"10.1039/C39950002127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antifungal antibiotic, polyoxin J 1, has been obtained (46.4%) by the coupling of a protected derivative of 5-O-carbamoylpolyoxamic acid 2 with thymine polyoxin C 3 which were prepared by a stereoselective aminohomologation strategy of sugar aldehydes (L-threose and dialdo-D-ribofuranose) employing nitrones 4 and 5 as their iminium derivatives and furan as a carboxylate group equivalent.\",\"PeriodicalId\":17282,\"journal\":{\"name\":\"Journal of The Chemical Society, Chemical Communications\",\"volume\":\"118 1\",\"pages\":\"2127-2128\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society, Chemical Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/C39950002127\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society, Chemical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/C39950002127","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 17

摘要

5- o-氨基甲酰聚肟酸2的保护衍生物与胸腺嘧啶多毒素c3通过糖醛(L-threose和dialdo- d -核糖呋喃糖)的立体选择氨基同源化策略，以硝基4和5为其亚衍生物，呋喃为其羧酸基衍生物，偶联制得抗真菌抗生素polyoxin j1(46.4%)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Total synthesis of (+)-polyoxin J

The antifungal antibiotic, polyoxin J 1, has been obtained (46.4%) by the coupling of a protected derivative of 5-O-carbamoylpolyoxamic acid 2 with thymine polyoxin C 3 which were prepared by a stereoselective aminohomologation strategy of sugar aldehydes (L-threose and dialdo-D-ribofuranose) employing nitrones 4 and 5 as their iminium derivatives and furan as a carboxylate group equivalent.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊