{"title":"高分子材料作为生物活性药物缓释载体的化学与物理结构研究进展","authors":"R. Langer, N. Peppas","doi":"10.1080/07366578308079439","DOIUrl":null,"url":null,"abstract":"Abstract In a controlled release system a drug, pesticide, or other bio-active agent is incorporated into a carrier, generally a polymeric material. The rate of release of the substance is determined by the properties of the polymer itself and is only weakly dependent on environmental factors (such as the pH of bodily fluids). Controlled release systems are capable of delivering substances slowly and continuously for up to several years.","PeriodicalId":16139,"journal":{"name":"Journal of Macromolecular Science-reviews in Macromolecular Chemistry and Physics","volume":"32 1","pages":"61-126"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"370","resultStr":"{\"title\":\"Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: A Review\",\"authors\":\"R. Langer, N. Peppas\",\"doi\":\"10.1080/07366578308079439\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract In a controlled release system a drug, pesticide, or other bio-active agent is incorporated into a carrier, generally a polymeric material. The rate of release of the substance is determined by the properties of the polymer itself and is only weakly dependent on environmental factors (such as the pH of bodily fluids). Controlled release systems are capable of delivering substances slowly and continuously for up to several years.\",\"PeriodicalId\":16139,\"journal\":{\"name\":\"Journal of Macromolecular Science-reviews in Macromolecular Chemistry and Physics\",\"volume\":\"32 1\",\"pages\":\"61-126\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"370\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Macromolecular Science-reviews in Macromolecular Chemistry and Physics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07366578308079439\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Macromolecular Science-reviews in Macromolecular Chemistry and Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07366578308079439","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: A Review
Abstract In a controlled release system a drug, pesticide, or other bio-active agent is incorporated into a carrier, generally a polymeric material. The rate of release of the substance is determined by the properties of the polymer itself and is only weakly dependent on environmental factors (such as the pH of bodily fluids). Controlled release systems are capable of delivering substances slowly and continuously for up to several years.