形态发生的几何学

N. Morozova, R. Penner
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引用次数: 8

摘要

我们介绍了真核细胞和生物体的几何形式。细胞被认为呈星形凸是有很好的生物学理由的。这样可以方便地描述它们在空间中的范围以及各种细胞表面梯度。我们假设这种细胞表面标记的光谱决定了生物体形状的表观遗传密码。空间中细胞在某一时刻的结合,根据定义是有机体作为欧几里得空间的度量子空间,它可以进一步配备任意测度。每个细胞确定空间中的一个点,从而为生物体分配空间中不同点的有限配置,并且在该配置空间上引入纤维希尔伯特空间,记录特定的表观遗传数据。在此基础上,提出了基于Gromov-Hausdorff距离的形态发生动力学的拉格朗日公式,该公式同时描述了胚胎发育和再生生长。
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Geometry of Morphogenesis
We introduce a formalism for the geometry of eukaryotic cells and organisms.Cells are taken to be star-convex with good biological reason. This allows for a convenient description of their extent in space as well as all manner of cell surface gradients. We assume that a spectrum of such cell surface markers determines an epigenetic code for organism shape. The union of cells in space at a moment in time is by definition the organism taken as a metric subspace of Euclidean space, which can be further equipped with an arbitrary measure. Each cell determines a point in space thus assigning a finite configuration of distinct points in space to an organism, and a bundle over this configuration space is introduced with fiber a Hilbert space recording specific epigenetic data. On this bundle, a Lagrangian formulation of morphogenetic dynamics is proposed based on Gromov-Hausdorff distance which at once describes both embryo development and regenerative growth.
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