毛细管电泳中使用脱氧胆酸胶束快速估计辛醇-水分配系数

Journal of The Chemical Society, Chemical Communications Pub Date : 1995-01-01 DOI:10.1039/C39950002241

M. Adlard, G. Okafo, E. Meenan, P. Camilleri

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引用次数: 24

摘要

脱氧胆酸胶束已成功地应用于毛细管电泳，估计了一些药物的辛醇-水分配系数(log P);该方法发展迅速，适用于各种结构的中性、碱性和弱酸性分子的理化参数的测定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rapid estimation of octanol–water partition coefficients using deoxycholate micelles in capillary electrophoresis

Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.

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