不溶性给药技术:健康效益和商业潜力综述

B. Siddalingappa, V. Nekkanti, G. Betageri
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引用次数: 12

摘要

第505(b)(2)条本节下的大部分保密协议都是新的配方。505(b)(2)填充物的新剂型、药物形态(酯/盐)的变化、药物的前药/活性代谢物以及不同给药途径是制药公司正在探索的少数变化。不溶性药物正在重新配制。因此,本文综述了各种增溶技术及其商业和健康效益。这篇综述讨论了药物制剂批准探索不同的增溶技术与洞察健康效益和商业利润。
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Insoluble drug delivery technologies: review of health benefits and business potentials
section 505(b)(2) 2 . The majority of those NDA’s under this section are new formulations. New dosage form, change of forms of drugs (Ester/salt), prodrug/active metabolite of drug and different route of administration are the few changes that the pharmaceutical companies are exploring for 505(b)(2) fillings 3 . The insoluble drugs are being reformulated. Hence this review summarises various solubilisation technologies and their commercial and health benefits. This review discusses drug formulations approved exploring different solubilisation technologies with insight to health benefits and commercial profits.
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