有脂质，会旅行吗

Science's STKE Pub Date : 2002-01-15 DOI:10.1126/scisignal.1152002tw21

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引用次数: 0

摘要

丝氨酸-苏氨酸激酶蛋白激酶D (PKD)在哺乳动物细胞中与反式高尔基网络(TGN)结合，并参与向质膜释放运输囊泡。Baron和Malhotra(见Bankaitis的观点)现在表明，为了使PKD与TGN结合，它必须特异性地与脂质二酰基甘油结合。当细胞中这种脂质浓度降低时，PKD向TGN的募集和TGN外的转运都受到抑制。C. L. Baron, V. Malhotra，二酰基甘油在PKD募集到TGN和蛋白质转运到质膜中的作用。科学295,325-328(2002)。【摘要】【全文】V. A. Bankaitis, Slick招募到高尔基人。科学295,290-291(2002)。(全文)

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Have Lipid, Will Travel

The serine-threonine kinase protein kinase D (PKD) binds to the trans-Golgi network (TGN) in mammalian cells and is involved in the release of transport vesicles destined for the plasma membrane. Baron and Malhotra (see the Perspective by Bankaitis) now show that in order for PKD to bind to the TGN, it must specifically bind to the lipid diacylglycerol. When concentrations of this lipid were reduced in cells, both PKD recruitment to the TGN and transport out of the TGN were inhibited. C. L. Baron, V. Malhotra, Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science 295, 325-328 (2002). [Abstract] [Full Text] V. A. Bankaitis, Slick recruitment to the Golgi. Science 295, 290-291 (2002). [Full Text]

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