Zn(OAc)2•2h2o催化5-取代1h -四唑的高效合成

Q2 Chemistry Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.3.005

Kokane Balaji Digambar, Dr. Ravi Varala, S. G. Patil

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引用次数: 1

摘要

在这篇论文中，用甲苯回流法从不同的芳香族、脂肪族和杂芳香族醛、羟胺和叠氮化钠缩合得到电子和结构上不同的四唑，收率在5-94%之间。采用Zn(OAc)2•2H2O (10 mol%)作为催化剂，具有环保、易得、经济等优点。利用红外、核磁共振和质谱研究对所有5-芳基四唑衍生物进行了全面的表征。该方法反应时间快，收率高，工艺安全，操作简单，是目前化学合成5-取代1h -四唑的一种吸引人的方便方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zn(OAc)2•2H2O-catalyzed efficient synthesis of 5-Substituted 1H-tetrazoles

In this communication, condensation from different aromatic, aliphatic and heteroaromatic aldehydes, hydroxyl amine, and sodium azide in toluene reflux was used to produce electronically and structurally distinct tetrazoles with a range of yields 5-94%. Zn(OAc)2•2H2O (10 mol%) was used as a catalyst in the synthesis, which was eco-friendly, readily available, and affordable. The IR, NMR, and mass spectral studies were utilized in order to carry out a comprehensive characterization for all the 5-aryl tetrazole derivatives. This approach contributes to the current chemical synthesis of 5-substituted-1H-tetrazoles in an appealing and convenient manner thanks to its quick reaction times, good to exceptional yields, safe process, and straightforward workup.

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.