{"title":"神经递质释放的钙依赖性","authors":"Gary Matthews, Henrique von Gersdorff","doi":"10.1006/smns.1996.0040","DOIUrl":null,"url":null,"abstract":"<div><p>Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca<sup>2+</sup>] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca<sup>2+</sup>] in this microdomain, together with the fast kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 5","pages":"Pages 329-334"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0040","citationCount":"13","resultStr":"{\"title\":\"Calcium dependence of neurotransmitter release\",\"authors\":\"Gary Matthews, Henrique von Gersdorff\",\"doi\":\"10.1006/smns.1996.0040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca<sup>2+</sup>] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca<sup>2+</sup>] in this microdomain, together with the fast kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.</p></div>\",\"PeriodicalId\":101157,\"journal\":{\"name\":\"Seminars in Neuroscience\",\"volume\":\"8 5\",\"pages\":\"Pages 329-334\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/smns.1996.0040\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044576596900408\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044576596900408","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca2+] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca2+] in this microdomain, together with the fast kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.
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