Management of a Jehovah's Witness patient with ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine

Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is defined as a systemic autoimmune disease limited to small calibre vasculature, associated with the presence of myeloperoxidase or proteinase 3. After receiving Pfizer BioNTech COVID-19 vaccine a 77-year-old woman of Jehovah's Witness faith presented with renal limited anti-MPO-AAV with underlying iron deficiency anaemia. Treatment was initiated with corticosteroids, iron repletion, Epoetin-beta, renal replacement therapy, plasma exchange with albumin, and cyclophosphamide with successful clearance of ANCA vasculitis. Although Jehovah's Witnesses may refuse transfusion of cellular blood products, they accept and expect alternative effective medical care.