Animal Models of Multiple Sclerosis: Imperfect but Imperative

Multiple sclerosis (MS) is a complex multifaceted disease involving autoimmune inflammation, demyelination and degeneration processes. The disease is heterogeneous in its clinical manifestation and progression, as well as in its pathological mechanisms [1]. Animal models have been indispensable for MS research. There is however, an ongoing controversy in regard to their true relevance to the human disease.