A Case of Bradycardia and Hypersensitivity with Intravenous Ketamine Monotherapy

Anaphylaxis during anesthesia is an unforeseeable and potentially life threatening syndrome that is dose independent. Ketamine is a widely used hypnotic for procedural sedation in the emergency department, in anesthesia and intensive care units (ICU). It is popularly employed for both children and adult patients. Though, dose dependent adverse effects of ketamine have been described, the hypersensitive reactions with the same are extremely rare. We are hereby presenting a case of an allergic reaction and isolated bradycardia with ketamine, given as intravenous monotherapy in a patient with no previous history of atopic disease. Our article aims at reminding all the medical professionals to never let a drug (however commonly used) throw away caution, be vigilant to timely diagnose an adverse drug reaction (even the most infrequent and rare) and be prepared to tackle the worst with the necessary supportive measures like hemodynamic support and advanced airway procedures.