Allen A Champagne, Nicole S Coverdale, Mike Germuska, Alex A Bhogal, Douglas J Cook
{"title":"体积和代谢参数的变化与头部受到亚撞击的程度不同有关。","authors":"Allen A Champagne, Nicole S Coverdale, Mike Germuska, Alex A Bhogal, Douglas J Cook","doi":"10.1177/0271678X19862861","DOIUrl":null,"url":null,"abstract":"<p><p>Structural and calibrated magnetic resonance imaging data were acquired on 44 collegiate football players prior to the season (<i>PRE</i>), following the first four weeks in-season (<i>PTC</i>) and one month after the last game (<i>POST</i>). Exposure data collected from g-Force accelerometers mounted to the helmet of each player were used to split participants into HIGH (<i>N</i> = 22) and LOW (<i>N</i> = 22) exposure groups, based on the frequency of impacts sustained by each athlete. Significant decreases in grey-matter volume specific to the HIGH group were documented at <i>POST</i> (<i>P</i> = 0.009), compared to baseline. Changes in resting cerebral blood flow (CBF<sub>0</sub>), corrected for partial volume effects, were observed within the HIGH group, throughout the season (<i>P</i> < 0.0001), suggesting that alterations in perfusion may follow exposure to sub-concussive collisions. Co-localized significant increases in cerebral metabolic rate of oxygen consumption (CMRO<sub>2</sub>|<sub>0</sub>) mid-season were also documented in the HIGH group, with respect to both <i>PRE</i>- and <i>POST</i> values. No physiological changes were observed in the LOW group. Therefore, cerebral metabolic demand may be elevated in players with greater exposure to head impacts. These results provide novel insight into the effects of sub-concussive collisions on brain structure and cerebrovascular physiology and emphasize the importance of multi-modal imaging for a complete characterization of cerebral health.</p>","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308522/pdf/","citationCount":"0","resultStr":"{\"title\":\"Changes in volumetric and metabolic parameters relate to differences in exposure to sub-concussive head impacts.\",\"authors\":\"Allen A Champagne, Nicole S Coverdale, Mike Germuska, Alex A Bhogal, Douglas J Cook\",\"doi\":\"10.1177/0271678X19862861\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Structural and calibrated magnetic resonance imaging data were acquired on 44 collegiate football players prior to the season (<i>PRE</i>), following the first four weeks in-season (<i>PTC</i>) and one month after the last game (<i>POST</i>). Exposure data collected from g-Force accelerometers mounted to the helmet of each player were used to split participants into HIGH (<i>N</i> = 22) and LOW (<i>N</i> = 22) exposure groups, based on the frequency of impacts sustained by each athlete. Significant decreases in grey-matter volume specific to the HIGH group were documented at <i>POST</i> (<i>P</i> = 0.009), compared to baseline. Changes in resting cerebral blood flow (CBF<sub>0</sub>), corrected for partial volume effects, were observed within the HIGH group, throughout the season (<i>P</i> < 0.0001), suggesting that alterations in perfusion may follow exposure to sub-concussive collisions. Co-localized significant increases in cerebral metabolic rate of oxygen consumption (CMRO<sub>2</sub>|<sub>0</sub>) mid-season were also documented in the HIGH group, with respect to both <i>PRE</i>- and <i>POST</i> values. No physiological changes were observed in the LOW group. Therefore, cerebral metabolic demand may be elevated in players with greater exposure to head impacts. These results provide novel insight into the effects of sub-concussive collisions on brain structure and cerebrovascular physiology and emphasize the importance of multi-modal imaging for a complete characterization of cerebral health.</p>\",\"PeriodicalId\":15356,\"journal\":{\"name\":\"Journal of Cerebral Blood Flow & Metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308522/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cerebral Blood Flow & Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/0271678X19862861\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/7/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cerebral Blood Flow & Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/0271678X19862861","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/7/15 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Changes in volumetric and metabolic parameters relate to differences in exposure to sub-concussive head impacts.
Structural and calibrated magnetic resonance imaging data were acquired on 44 collegiate football players prior to the season (PRE), following the first four weeks in-season (PTC) and one month after the last game (POST). Exposure data collected from g-Force accelerometers mounted to the helmet of each player were used to split participants into HIGH (N = 22) and LOW (N = 22) exposure groups, based on the frequency of impacts sustained by each athlete. Significant decreases in grey-matter volume specific to the HIGH group were documented at POST (P = 0.009), compared to baseline. Changes in resting cerebral blood flow (CBF0), corrected for partial volume effects, were observed within the HIGH group, throughout the season (P < 0.0001), suggesting that alterations in perfusion may follow exposure to sub-concussive collisions. Co-localized significant increases in cerebral metabolic rate of oxygen consumption (CMRO2|0) mid-season were also documented in the HIGH group, with respect to both PRE- and POST values. No physiological changes were observed in the LOW group. Therefore, cerebral metabolic demand may be elevated in players with greater exposure to head impacts. These results provide novel insight into the effects of sub-concussive collisions on brain structure and cerebrovascular physiology and emphasize the importance of multi-modal imaging for a complete characterization of cerebral health.