Orta ve ağır akciğer tutulumu olan kistik fibrozlu hastalarda ölüme etki eden diğer risk etmenleri

Aim: Severe pulmonary disease is responsible for over 80 of deaths associated with cystic fibrosis Our aim was to evaluate the other risk factors associated with mortality in patients with cystic fibrosis who have moderate and severe lung disease Material and Method: Among 200 patients with cystic fibrosis who were followed up in our clinic 35 patients with moderate and severe lung disease FEV1 predicted le;60 were included in the study Demographic data pulmonary function tests high resolution thorax tomography modified Bhalla score blood gas analysis and nutritional status of the patients were evaluated Results: Requirement for respiratory support was 31 4 in moderate and severe lung disease Lower pulmonary function requirement for non invasive ventilation presence of diabetes mellitus a Sa02 value of lt;95 a value of pCO2 gt;50 mm Hg and requirement for frequent IV antibiotics were significantly related with increased mortality Conclusions: This is a single centre study conducted in patients with cystic fibrosis who had moderate and severe lung disease and who had not received lung transplantation We evaluated the clinical outcome and other factors that were associated with mortality Turk Arch Ped 2012; 47: 267 71