Uday sankar raju K, Vimalakkannan T, K. Ravindra Reddy, P. Naveena, R. Riharika raj, S. Chinna subbarayudu, T. Hima bindu
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Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry
A simple, rapid and precise method is developed for the quantitative determination of Fluoxetine in combined pharmaceutical-dosage forms. The method was based on UV Spectrophotometric determination of Fluoxetine drug using Beer-Lamberts Law. It involves absorbance measurement at 224 nm (λmax of Fluoxetine) in water. For UV Spectrophotometric method, linearity was obtained in concentration range of 5-30 mcg/ml with regression 0.999 for Fluoxetine respectively. Recovery was in the range of 98 -102%; the value of standard deviation and %R.S.D was found to be < 2 shows high precision of the method..
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