紫外分光光度法测定氟西汀原料药和剂型的新分析方法的建立与验证

Uday sankar raju K, Vimalakkannan T, K. Ravindra Reddy, P. Naveena, R. Riharika raj, S. Chinna subbarayudu, T. Hima bindu
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引用次数: 1

摘要

建立了一种简便、快速、准确的测定复方氟西汀含量的方法。建立了用比尔-兰伯特定律紫外分光光度法测定氟西汀的方法。它涉及在224 nm(氟西汀的λmax)水中的吸光度测量。紫外分光光度法测定氟西汀浓度在5 ~ 30 mcg/ml范围内线性良好,回归系数为0.999。回收率在98 ~ 102%之间;标准偏差和% rs的值发现D < 2表明该方法精度高。
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Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry
A simple, rapid and precise method is developed for the quantitative determination of Fluoxetine in combined pharmaceutical-dosage forms. The method was based on UV Spectrophotometric determination of Fluoxetine drug using Beer-Lamberts Law. It involves absorbance measurement at 224 nm (λmax of Fluoxetine) in water. For UV Spectrophotometric method, linearity was obtained in concentration range of 5-30 mcg/ml with regression 0.999 for Fluoxetine respectively. Recovery was in the range of 98 -102%; the value of standard deviation and %R.S.D was found to be < 2 shows high precision of the method..
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