Colorectal Cancer in Adolescence: A Report of Two Cases

Background Colorectal cancer is very rare in children. Therefore, the diagnosis is generally established at advanced disease. This is a presentation of two cases of colorectal treated at Habib Bourguiba Hospital University. Case presentation Two adolescents, 14-year-old and 16-year-old were treated for CRC between 2006 and 2022 in our department. Both complained about abdominal and pelvic pain few months ago. The first patient, with no personal or family history of digestive pathology, was admitted for peritonitis. The exploration noted advanced rectal tumor, peritoneal carcinomatosis and bone metastasis. She had one cycle of palliative FOLFIRI chemotherapy and died. The other one was admitted for complicated appendicitis. Per operative exploration noted localized sigmoid tumor which was resected. She had 12 cycles of adjuvant FOLFOX chemotherapy and she was alive and free failure for 13 years. Her paternal uncle had yet rectal cancer at 40 years and her father developed later metastatic colon cancer. Lynch syndrome was established.