{"title":"甾体分子三氟甲基化的新便捷途径","authors":"X. Fei, W. Tian, Qing‐Yun Chen","doi":"10.1039/A706552C","DOIUrl":null,"url":null,"abstract":"A new convenient route for direct trifluoromethylation of steroidal compounds is described. Steroidal alkenyl bromides, derived from steroidal unsaturated ketones, react with FO2SCF2CO2Me in the presence of CuI in DMF to give the corresponding trifluoromethylated steroids in good yields (70–91%).","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"16 1","pages":"1139-1142"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"22","resultStr":"{\"title\":\"New, convenient route for trifluoromethylation of steroidal molecules\",\"authors\":\"X. Fei, W. Tian, Qing‐Yun Chen\",\"doi\":\"10.1039/A706552C\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new convenient route for direct trifluoromethylation of steroidal compounds is described. Steroidal alkenyl bromides, derived from steroidal unsaturated ketones, react with FO2SCF2CO2Me in the presence of CuI in DMF to give the corresponding trifluoromethylated steroids in good yields (70–91%).\",\"PeriodicalId\":17267,\"journal\":{\"name\":\"Journal of The Chemical Society-perkin Transactions 1\",\"volume\":\"16 1\",\"pages\":\"1139-1142\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"22\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society-perkin Transactions 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/A706552C\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society-perkin Transactions 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A706552C","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
New, convenient route for trifluoromethylation of steroidal molecules
A new convenient route for direct trifluoromethylation of steroidal compounds is described. Steroidal alkenyl bromides, derived from steroidal unsaturated ketones, react with FO2SCF2CO2Me in the presence of CuI in DMF to give the corresponding trifluoromethylated steroids in good yields (70–91%).
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