Association between Hypertension and Insulin resistance in non-diabetic adult populations: a community-based study from the Center of Iran

Backgrounds and Objectives: High blood pressure increases the probability of insulin resistance and hyperinsulinemia. Also, insulin resistance can be defined as a risk factor for hypertension. The present study was investigated the relationship between hypertension and insulin resistance in non-diabetic participants who referred to Qazvin Metabolic Diseases Center. Materials and Methods: In this cross sectional study 1103 participants (111 non diabetic with newly diagnosed hypertension and 992 normotensive subjects aged ≥20 years) were enrolled from September 2014 to April 2016 in Qazvin (Iran). Systolic and diastolic blood pressure, Insulin resistance, waist circumference, body mass index, triglycerides ,cholesterol, LDL-cholesterol, FBS were measured. Fasting triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) was used as a surrogate of insulin resistance. Data were analyzed using SPSS software and P < 0.05 were assumed as significant level. Results: 10% of all participants had hypertension. TG/HDL-C was 3.78 ±3.28 in non-HTN and 5.76±5.35 in HTN participants, respectively(P < 0.001). The frequency of all cardio-metabolic risk factors (except HDL cholesterol level) was higher than others after adjusting of age and gender in hypertensive group(P < 0.001). Conclusion: Based these results, essential hypertension is associated with a higher prevalence of hyperinsulinemia and insulin resistance in the non-diabetic community in Iran.