Multiple Sclerosis and Gene Polymorphisms: are we Groping in the Dark?

Copyright: © 2015 Haq E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Till date, the etiology of multiple sclerosis (MS) remains convoluted and many recent studies have added some startling findings to the existing literature on MS. There have been some noticeable developments in dissecting genetics of MS, but the results remain controversial due to divergence in geographic prevalence of MS across different populations. By and large this may be attributed to the enigmatic genetic and environmental background in its etiopathogenesis. By unlocking the missing link between these two components, some advancement can be achieved in devising better treatment options for MS management. This commentary highlights the outcome of our recent study aimed at exploring the association between MS susceptibility and EIF2B5 Ile587Val polymorphism in a subset of Indian population [1].