Aminoethylpiperazine Based Metal Schiff Base Complexes: Catalytic and Biological Activities

ABSTRACT Piperazine, a six-membered nitrogen-based heterocycle, is widely distributed in nature and also has great therapeutic efficacy due to abundant of large number of biomolecules with multiple functions. Owing to the activities, developments of piperazine-based compounds are receiving great attention among the research chemists. Nowadays, piperazine and its various homologues exhibit various biological roles such as antibiotics, anticancer, antimicrobial, antipsychotics and antidepressants. In this context, various piperazine-based metal-Schiff base complexes have been synthesized to investigate their catalytic and biological activity. In addition, a large number of Schiff base transition metal compounds have been reported which play a significant role in biology due to their potential antimicrobial, antifungal, antitumor, antiviral and antidiabetic properties. The present review encompasses the applications of various aminoethylpiperazine-based metal Schiff base complexes. Aminoethylpiperazine is one of important structural motifs which have different active sites/structural features and capable to bind with the metal ion to form chelate ring and also explore biological and catalytic properties of its Schiff base-based metal organic complexes. This review mainly focused on the catalytic and biological importance of aminoethylpiperazine-based metal organic complexes during the period of 2012–2020.