细胞免疫指标在急性视神经炎综合治疗中的动态变化

D. Storozhilova, O. V. Kolenko, L. Danilova, L. P. Emanova, I. Vasilieva
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引用次数: 0

摘要

视神经炎在劳动年龄人群中发病率的增加,以及视神经萎缩的发展导致视力预后不佳,决定了这一问题的高度社会意义。本工作的目的是分析免疫凡在细胞免疫和疾病临床症状参数下对疱疹病毒感染相关视神经炎的综合治疗效果。该研究涉及37人(37只眼睛)与疱疹感染相关的急性视神经炎。治疗方案包括:按减量方案使用地塞米松溶液,1%莫西平溶液0.5 mL和12.5%迪赛诺溶液0.5 mL,通过球后间隙灌洗系统植入,联合使用神经保护药物(pickamilon和Semax) 10天。所有患者分为两组。主要组为20例在治疗方案基础上加用免疫凡的患者。对照组17例患者仅按上述方法治疗。疗程为10 d。数据分析显示,在接受免疫治疗的患者中,细胞免疫参数有更显著的正动态变化。我们的研究表明,这种药物在疱疹感染相关视神经炎的复杂治疗中是有效的,这一点可以通过炎症缓解的加速、使用免疫凡治疗的患者视觉功能的更显着增加和视神经萎缩的比例更低来证实。在这组患者中,免疫细胞环节参数的变化发生得更早,并在整个观察期间保持稳定。根据我们的数据,免疫调节指数的组间评估显示,对照组接受免疫粉治疗的患者的免疫调节指数上升更快,并且在治疗6个月后已达到正常值。在12个月的观察期内,免疫凡对疱疹感染相关视神经炎综合治疗的临床效果表现为:视神经炎症症状缓解期缩短2倍或更多,最大矫正视力提高4.5倍,视神经炎复发率降低2倍。
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Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis
An increase in the incidence of optic neuritis among the working-age population, as well as an unpromising prognosis for vision due to the development of optic nerve atrophy, determines the high social significance of this problem. The aim of the work is to analyze the effect of Imunofan at the parameters of cellular immunity and clinical symptoms of the disease in the complex treatment of optic neuritis associated with herpes virus infection. The study involved 37 people (37 eyes) with acute optic neuritis associated with herpes infection. The treatment regimen included the appointment of a dexamethasone solution according to a decreasing scheme, a 1% solution of the drug Emoxipin 0.5 mL and a 12.5% solution of the drug Dicynone 0.5 mL through an irrigation system implanted in the retrobulbar space, in combination with the neuroprotection drugs (Pikamilon and Semax) for 10 days. All patients were divided into 2 groups. The main group consisted of 20 patients who received Imunofan to the treatment regimen in addition. The comparison group included 17 patients who were treated only according to the method described above. The course of treatment lasted 10 days. The analysis of the data showed a more significant positive dynamics of cellular immunity parameters in those who received immunotherapy. Our studies showed the effectiveness of this drug in the complex treatment of optic neuritis associated with herpes infection, what is confirmed by the acceleration of inflammation relief, a more significant increase in visual functions of patients treated with Imunofan, and a lower percentage of optic nerve atrophy. In this group of patients, changes in the parameters of the cellular link of immunity occurred earlier and remained stable throughout the entire period of observation. According to our data, an intergroup assessment of the immunoregulatory index showed its faster increase in patients of the comparison group who received Imunofan, and reached normal values already 6 months after treatment. The clinical effectiveness of Imunofan in the complex therapy of optic neuritis associated with herpes infection was characterized by a reduction in the period of relief of signs of inflammation in the optic nerve by 2 times or more, by an increase in the maximum corrected visual acuity by 4.5 times, and by a decrease in the incidence of recurrence of optic neuritis by 2 times over a 12 months observation period.
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来源期刊
Medical Immunology (Russia)
Medical Immunology (Russia) Medicine-Immunology and Allergy
CiteScore
0.70
自引率
0.00%
发文量
88
审稿时长
12 weeks
期刊介绍: The journal mission is to promote scientific achievements in fundamental and applied immunology to various medical fields, the publication of reviews, lectures, essays by leading domestic and foreign experts in the field of fundamental and experimental immunology, clinical immunology, allergology, immunodiagnostics and immunotherapy of infectious, allergy, autoimmune diseases and cancer.
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