Miroslav Veselý, B. Gál, J. Rottenberg, M. Páleník, J. Hanak, D. Zicha
{"title":"相干控制全息显微镜-一种检测头颈部鳞状细胞癌新生物标志物的工具。","authors":"Miroslav Veselý, B. Gál, J. Rottenberg, M. Páleník, J. Hanak, D. Zicha","doi":"10.48095/ccko2022128","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nSquamous cell carcinoma of the head and neck is characterized by local invasiveness and metastases to regional lymph nodes. In 60% of cases, these tumours are dia-gnosed at an advanced stage, and the prognosis is unfavorable. One of the important factors of local, hematogenous or lymphogenic spread of the tumour in the human body is tumour cells migration ability. Advanced microscopic methods provide a new perspective on cell migration.\n\n\nPURPOSE\nThis paper presents a coherence controlled holographic microscopy method that provides a non-invasive quantitative evaluation of morphological and dynamic properties of living tumour cells. In connection with this method, new potential bio-markers are emerging, the significance of which, however, needs to be verified by correlation with clinical data.","PeriodicalId":35565,"journal":{"name":"Klinicka Onkologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coherence controlled holographic microscopy - a tool for detection of new biomarkers of head and neck squamous cell carcinoma.\",\"authors\":\"Miroslav Veselý, B. Gál, J. Rottenberg, M. Páleník, J. Hanak, D. Zicha\",\"doi\":\"10.48095/ccko2022128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nSquamous cell carcinoma of the head and neck is characterized by local invasiveness and metastases to regional lymph nodes. In 60% of cases, these tumours are dia-gnosed at an advanced stage, and the prognosis is unfavorable. One of the important factors of local, hematogenous or lymphogenic spread of the tumour in the human body is tumour cells migration ability. Advanced microscopic methods provide a new perspective on cell migration.\\n\\n\\nPURPOSE\\nThis paper presents a coherence controlled holographic microscopy method that provides a non-invasive quantitative evaluation of morphological and dynamic properties of living tumour cells. In connection with this method, new potential bio-markers are emerging, the significance of which, however, needs to be verified by correlation with clinical data.\",\"PeriodicalId\":35565,\"journal\":{\"name\":\"Klinicka Onkologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Klinicka Onkologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.48095/ccko2022128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Klinicka Onkologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.48095/ccko2022128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Coherence controlled holographic microscopy - a tool for detection of new biomarkers of head and neck squamous cell carcinoma.
BACKGROUND
Squamous cell carcinoma of the head and neck is characterized by local invasiveness and metastases to regional lymph nodes. In 60% of cases, these tumours are dia-gnosed at an advanced stage, and the prognosis is unfavorable. One of the important factors of local, hematogenous or lymphogenic spread of the tumour in the human body is tumour cells migration ability. Advanced microscopic methods provide a new perspective on cell migration.
PURPOSE
This paper presents a coherence controlled holographic microscopy method that provides a non-invasive quantitative evaluation of morphological and dynamic properties of living tumour cells. In connection with this method, new potential bio-markers are emerging, the significance of which, however, needs to be verified by correlation with clinical data.